Infectious Diseases

In veiw of new GBS guidlines, I have a question; what to do with a term baby with history of prolonged ruptur of membrane for 4 days and maternal GBS status was negative, no chorioamnionitis, and baby is asymptomatic. what to do if mother received anitibiotics and if she did not receive antibiotics. Thanks

I want to ask this question to group that what is their practice of isolating RSV, Adenovirus, Infleunza and Para infleunza viruses infection in their units. 1) Do you isolate the index cases in separate rooms by removing them from main stream? 2) What about those who are exposed to index cases? How long do you keep them isolated ( Gloves, gowns, mask etc) 3) Or you isolate them case by case, no need to isolate them in separate room, but practice contact or droplet precautions at the same place 4) What happens when you donot have rooms to isolate the index cases either they are large in number or you donot have isolation rooms. Thanks

A question for the group. This new guideline apply to every gestational age. I just came up with a of a set twins that were born prematurely at 32+ weeks. Mother GBS status was unknown, babies were delivered by c-section due to breech presentation in one of them. ROM was at delivery. Both babies were born vigorous and transition without issues. The continued asymptomatic at a week of life. I decided to consider the recommendations of the 2010 GBS guidelines and did not start them on antibiotics. A CBC was reassuring and BCx was negative at 48hrs. Before the 2010 guideline, I would start any 34weeks or < preterm asymptomatic baby on antibiotics if the reason for preterm…

What is the significance of high total leucocyte count as a part of routine and or septic screening?

Dear all! I need an advice. In our NICU recently there were some newborns with the same clinic. At the age of 2-3 weeks they show intestinal problems , increasing of lactate. In laboratory indicators: a neytropenia, thrombocytopenia, at some - an eosinofilia, negative CRP, sometimes positive PCT, sometimes not. Blood culture is always negative, we don't register neither viruses, nor fungi, and bacteria (microbiology, PCR). The condition of newborns worsens, the lactate acidosis increases, we evaluate the situation as sepsis and use antibiotics, but we do not see effect. What can it be? Why antibiotics (we used imipenems, metronidazol, vankomycine, cephalosporines, linez…

Treatment of Neonatal Sepsis with Intravenous Immune Globulin . Background Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of trials of intravenous immune globulin for suspected or proven neonatal sepsis suggest a reduced rate of death from any cause, but the trials have been small and have varied in quality. Methods At 113 hospitals in nine countries, we enrolled 3493 infants receiving antibiotics for suspected or proven serious infection and randomly assigned them to receive two infusio…

Dear NICU netters, As we all know, prolonged ( > 2days) antibiotic therapy is harmful in very low birth weight infants. Is there any justification in continuing antibiotics for 7 days in spite of negative cultures? For instance, a 26 week delivered by C section for severe maternal PIH has absolute neutrophil count of 700 but blood culture is negative. Would you treat this infant with prolonged course of antibiotics? Appreciate your thoughts Mike

The best and most simple online authoritative antibiotic guide in my opinion is JHU ABX GUIDE Most importantly it is regularly updated It is freely available to all after you do a one time registration. I find it very helpful in day to day practice when you want to clarify "doubts" on the drugs you use Hope you will also find it useful

Dear Members, We have treated a 25 days old baby born at 34 weeks of gestational age for a devastating late onset GBS meningitis. Her sister (monochorial twin) is colonized by GBS and swabs are still positive to streptococcus after 2 weeks of treatment with amoxicillin and probiotics. We also treated parents with same drugs. The healthy sister, of course, is very well, but parents (and we too) are very worried. Please, could anyone give a suggestion about a correct management of the baby? Many Thanks Marcello De Filippo Neonatal subintensive care unit Grosseto Hospital - Italy

Do you - in your countries vaccinate preterm infants in the same way as term ones? Do you perform first vaccination in hospital or after discharge? Maybe someone could suggest articles about vaccination of preterm babies - indications, contraindications, possible side effects...