Gustaf Lernfelt

I’ve only seen the approach were you find yourself with a problematic tube that need constant suctioning, and then you take a culture to see if there is Ureaplasma present that might(?) induce increased mucus production. If present, a course of azithromycin is provided. However, a colleague mentioned that their previous unit abroad gave prophylactic azithromycin to all extreme preterms, both to target Ureaplasma and to leverage its anti-inflammatory effects.

I have reached out to one of the coauthors, and will get back to you if I get any good answer 🙂.

Thank you for the fantastic, incredibly thorough review of each drug. It is truly inspiring; we usually rush into decisions after a brief glance at clinical support tools. Based on your detailed insights, we feel confident offering the family a partial breastfeeding plan combined with regular monitoring of drug concentrations and routine labs, similar to standard antiepileptic treatment. Our plan is to let the mother establish breastfeeding while aiming for the infant to receive 50% of their intake via preterm-adapted formula, ensuring bottle feeding for at least 4 meals a day. For context, the child's initial carbamazepine concentration came back well below therapeutic levels. We have sent out a sample for Briviact analysis to an external lab and are currently awaiting those results. This has been immensely helpful for our clinical reasoning, thank you again

I'm working at one of the intervention sites in the study After the inclusion period finished we continued to use it for all affected infants according to the treatment indication of the study, and still do. Were there any particular questions you had regarding the results and the treatment? I might not be able to answer the ophthalmologic questions myself, but could get back to you with an answer from one of the authors.

Dear NICU-colleagues I would like your expertise in a patient case. We have a preterm infant born at 28+2 weeks of gestation following PPROM and chorioamnionitis, treated with SALSA for RDS, and subsequently managed on HFNC until a week ago. The infant is now at 34+0 weeks postmenstrual age and is off all respiratory support. Aside from this, the infant is very healthy, with no IVH, no PDA, and adequate growth. Enteral nutrition was initiated with donor breast milk, and the infant reached full enteral feeds of 150 mL/kg by 7 days of age. The infant’s mother has complex epilepsy and was maintained on Tegretol (carbamazepine) 800 mg + 1200 mg/day, Briviact (brivaracetam) 200 mg + 200 mg/day, and mirtazapine 45 mg once daily throughout the entire pregnancy. She began pumping early on and expressed a strong desire to feed the baby with her own milk. Initially we were hesitant, however, given her strong wishes and our goal to promote the use of mother's own milk, we have permitted partial feeding with MOM 12 mL out of 50 mL per feed, 8 times a day. The infant currently weighs 2340 g. We now need to decide whether to allow her to transition to full breastfeeding. While we do use Briviact to treat some of our pediatric patients, this scenario presents a complex preterm polypharmacy issue, and our experience with Briviact safety during breastfeeding is limited. The straightforward approach would be to transition directly to formula, but the mother has worked incredibly hard for this, and we want to support her wishes if it is safe to do so. I read @Dotan S framework on polypharmacy (https://www.nature.com/articles/s41390-025-04416-z) and I know that @Mariana Oliveira usually has great insights on this topic. What would be an acceptable approach according to you? Allt toughts are welcome to help us make the most reasonable decision. Best Gustaf

This is absolutely brilliant and should be published as an article. Thank you Brar 🙏! We do use single use sterile gel for our most vulnerable patients, like in examinations before rickham reservoir taps, and in US-guided venous puncture / picc-line insertions. In older premature infants a heated multi use-bottle is more common (which feels great for bacterial culture 😱). We do also see lack of cleaning post examinations sometimes, with residue still on the probe as you mention. It does feel reassuring that our solution still Is a viable choice, as long as staff is coherent to routines. Thank you once more, for sharing your knowledge and providing such a thorough and well thought out answer. All the best, Gustaf

We rarely send them home on caffeine unless an underlying neurological cause for central apnea is suspected. Our standard protocol involves treating extremely premature infants until 33–34 weeks gestation, followed by a 5-day observation period prior to discharge. Some mature preemies who don't need respiratory support can be discontinued earlier. Some of the infants will still have intermittent desaturations because of BPD, requiring home oxygen, or a symptomatic PDA and get a bit swollen which we manage with a short course of diuretics. But if the reason for the desaturation isn't central, no caffeine. All infants are monitored with apnea alarms until 35 weeks, provided saturations remain stable enough to discontinue extra O2 and pulse oximetry. It feels more reasonable to try and address the specific underlying etiology than everything for all.

I had a discussion with our IPC-nurse. After spending a year at our nearest level-4 unit where there was a problem with intermittent spread of nosocomial infections (viral as well as kleb and serratia), I wanted to change our routines regarding cleaning of ultrasonography probes. Currently, we are using 45 vol% isopropyl alcohol with added tensides.I tried to change into a combination of Kiilto Pro Cleanisept wipes ( with Didecylmetylammonium chloride, Alkylbensyldimetylammonium chloride and Alkyletylbensyldimetylammonium chloride) and 70 percent ethanol disinfection—wipes, as adopted in the other unit to limit nosocomial spread of pathogens in our unit. But since our IPC-nurse said it was not necessary they decided to continue with our current protocol because it was cheaper. Do you have any specific knowledge on how to approach the possible spread of nosochomial infections through ultrasound devices as POCUS becomes more established in every unit? Are there any good guidelines? I have a worry that our IPC-unit does not have the full neonatal perspective on things. All the best,

Very welcome! This sounds great, I do have a NeoIPC-question I would need to consult you about! Or at least two! Do we have a dedicated forum for this?

Swedish guidelines are Fluconazole 3 mg/kg every 3 days in <27W with central lines or / and during treatment with antibiotics. To be removed when neither is present. Can also be considered in cases where broad spectrum antibiotics are used in <30W when suspected intentestinal injury (or recent surgery). References are here, newest publication from 2017: https://pubmed.ncbi.nlm.nih.gov/28285752/ https://pubmed.ncbi.nlm.nih.gov/27298330/ https://pubmed.ncbi.nlm.nih.gov/27350534/ https://pubmed.ncbi.nlm.nih.gov/17943803/

My limited experience, from rotation at a Level 4 center in Sweden that uses Premiloc-dosing for all infants <28W, is that the results are generally positive. It seems to help with stabilising BP, and when maternal infection is a factor, there’s often a need for extra hydrocortisone. Side effects like hyperglycemia are usually manageable with fluid adjustments, but in some cases the infant will need supplemental insuline. The Swedish experience was published not long ago ( https://pubmed.ncbi.nlm.nih.gov/41712209/ ), though it’s hard to reach statistical significance in the micropreemie group given the small numbers, and to correct for differences in ventilation strategies between centers, the overall outcome was positive. While my experience with these patients is very limited, I do trust my seniors who’s says it’s a solid strategy. The only Swedish center involved in the Tiny Baby collaboration has not adapted this strategy as far as I know. I attended a course in extreme prematurity there a few years ago, and the recommendation then was that supplemental corticosteroids should be avoided.

I would say this is what Linkedin is for.

I rarely see this in my own unit, but I came across a case during my rotation at the Level 4 NICU, linked to a traumatic birth. One of our most experienced consultants noted that while it used to be more common, better nursing care during hypothermia treatment has made it a rare occurrence today. We diagnose it clinically and monitor ionized calcium levels every two weeks. If severe hypercalcemia, we restrict vitamine-D and start treatment with prednisone, not sure about dosing though.