Hematological Conditions

My first post in your forum. Congratulations and keep up the good work. I would like to know your clinical prctice regarding diagnosis and management of NAIT. 1. Which combination of clinical symptoms and lab results are suggesting NAIT, taking into consideration that current anti platelet Ab detection has a high rate of false negatives? 2. What kind of trnsfusion product do you use. Random donor platelets, do you have typed platelets, do you perform mother platelet apheresis? 3. Have you come across any non-responders? 4. What about genetic councelling to parents of NAIT neonates? Dimtris Anastasiou Neonatology Resident Athens, Greece

Our new poll for November is out. We are curious about your answers! Also check out the editorial article (here)

Just wanted to inform the members, that the 9th edition of "Antithrombotic Therapy in Neonates and Children: Antithrombotic Therapy and Prevention of Thrombosis" from American College of Chest Physicians is out. Link

Dear colleagues! I meet a cases with different hemorrhage locations (4 intracranial, 1 in adrenal hematomas in both glands). All stories communicated with low-molecular- weight heparin use in pregnancy. Some later I sow in literature a case about subdural intrauterine hematoma of fetus associated with low-molecular- weight heparin use. Do you have information about complications in newborns after heparin administration in pregnancy? Thanks to you. Alex.

Hi, I recently heard of a case of an infant born at term from an apparently uncomplicated pregnancy. Mother of the infant with h/o sickle cell trait. Mother visited the OB doctor at 40 weeks due to painful contractions. Questionable decreased fetal movements was recollected on further questioning, but no clear on initial presentation. Mother was admitted to L&D due to active labor. A stat c-section was performed after 4hrs of labor due to a category III fetal heart tracing (with absence of variality). A severely depressed infant was born through meconium-stained amniotic fluid. ET intubation was performed, but no mec was seen below the glottis. PPV was initiated due…

Thrombocytopenia: Neonatal Alloimmune (Isoimmune) severe, with platelet counts often ≤10,000/μL in the first day of life. The maternal platelet count is normal increase risk for intracranial hemorrhage, both prenatally and postnatally. diagnosis: clinical The treatment: transfusion of washed irradiated maternal platelets. Irradiated, random-donor platelet if active bleeding & maternal platelets are not immediately available. Intravenous γ-globulin (1 g/kg daily for 2 days) or corticosteroids ( methylprednisolone 2 mg/kg per day), or both Elective cesarean section has been advocated for infants at risk Thrombocytopenia Result…

One of our term newborn presented thrombocytopenia (with antibodies maternal IgG) and neutropenia (with maternal HLA antibodies), hours after transfusion of platelets and Ig Vena and Neupogen is better. Has anyone had any cases in which thrombocytopenia is associated with neutropenia? parents are South Americans. Thanks.

A 29 2/7 weeks male infant was born two days ago from a 25 y/o G1P0 healthy pregnant mom. MOC showed up in preterm labor, with PPROM, and infant was born by CS due to NRFHT. Apgars 2 and 8. Infant intubated at delivery, given curosurf and weaned from the vent over 6hours. Tolerated HFNC at 5 lpm, on 20's FiO2. Amp and Gent started for suspected sepsis. Maternal serology was negative, (HIV, RPR, GBS). No maternal chorio. A CBC at 24 HOL showed WBC in the 65k, with 19% Bands, 11% myelos, 7% meta. Baby otherwise clinically stable. No phenotypic features of down syndrome. 1- What causes this phenomenum? 2- How log does it ussually last? 30 any reference article of idipatht…

Hello Everyone, I am intrigued to learn what your views are on determining whether reticulocyte counts have a bearing on your decision to transfuse or not, and whether or not you have a set guideline. Thanks Alistair

In your opinion what is the safe HB at which to send the newborn home ?. This question arose because we had few newborn who had persistently low HB since birth. We try to keep the haemotocrit to above 45 in sick newborns. Does the same applies here? dr.r.selvan Erode, India